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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
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1993 1
1994 3
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2000 1
2001 2
2002 2
2003 1
2004 1
2005 1
2006 2
2007 6
2008 3
2009 1
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2011 5
2012 1
2013 3
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1,032 results

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Pan-cancer single-cell landscape of tumor-infiltrating T cells.
Zheng L, Qin S, Si W, Wang A, Xing B, Gao R, Ren X, Wang L, Wu X, Zhang J, Wu N, Zhang N, Zheng H, Ouyang H, Chen K, Bu Z, Hu X, Ji J, Zhang Z. Zheng L, et al. Science. 2021 Dec 17;374(6574):abe6474. doi: 10.1126/science.abe6474. Epub 2021 Dec 17. Science. 2021. PMID: 34914499
We built a single-cell RNA-sequencing pan-cancer atlas of T cells for 316 donors across 21 cancer types and revealed distinct T cell composition patterns. We found multiple state-transition paths in the exhaustion of CD8(+) T …
We built a single-cell RNA-sequencing pan-cancer atlas of T cells for 316 donors across 21 cancer types a …
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.
Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W, Peng J, Zhang Z. Zheng C, et al. Cell. 2017 Jun 15;169(7):1342-1356.e16. doi: 10.1016/j.cell.2017.05.035. Cell. 2017. PMID: 28622514 Free article.
Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of immunotherapies and the prediction of their clinical responses in cancers. Here, we perform deep single-cell RNA sequencing on 5,063 single T cells is …
Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of immunotherapies and the prediction of their clinical …
Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus.
Perez RK, Gordon MG, Subramaniam M, Kim MC, Hartoularos GC, Targ S, Sun Y, Ogorodnikov A, Bueno R, Lu A, Thompson M, Rappoport N, Dahl A, Lanata CM, Matloubian M, Maliskova L, Kwek SS, Li T, Slyper M, Waldman J, Dionne D, Rozenblatt-Rosen O, Fong L, Dall'Era M, Balliu B, Regev A, Yazdany J, Criswell LA, Zaitlen N, Ye CJ. Perez RK, et al. Science. 2022 Apr 8;376(6589):eabf1970. doi: 10.1126/science.abf1970. Epub 2022 Apr 8. Science. 2022. PMID: 35389781 Free PMC article.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains incomplete. We profiled more than 1.2 million peripheral blood mononuclear cells (162 cases, 99 controls) with multip …
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states assoc …
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.
Guo X, Zhang Y, Zheng L, Zheng C, Song J, Zhang Q, Kang B, Liu Z, Jin L, Xing R, Gao R, Zhang L, Dong M, Hu X, Ren X, Kirchhoff D, Roider HG, Yan T, Zhang Z. Guo X, et al. Nat Med. 2018 Jul;24(7):978-985. doi: 10.1038/s41591-018-0045-3. Epub 2018 Jun 25. Nat Med. 2018. PMID: 29942094
To depict the baseline landscape of the composition, lineage and functional states of tumor infiltrating lymphocytes, here we performed deep single-cell RNA sequencing for 12,346 T cells from 14 treatment-naive non-small-cell lung cancer …
To depict the baseline landscape of the composition, lineage and functional states of tumor infiltrating lymphocytes, here we performed deep …
Single-Cell RNA-Seq of T Cells in B-ALL Patients Reveals an Exhausted Subset with Remarkable Heterogeneity.
Wang X, Chen Y, Li Z, Huang B, Xu L, Lai J, Lu Y, Zha X, Liu B, Lan Y, Li Y. Wang X, et al. Adv Sci (Weinh). 2021 Oct;8(19):e2101447. doi: 10.1002/advs.202101447. Epub 2021 Aug 8. Adv Sci (Weinh). 2021. PMID: 34365737 Free PMC article.
Here, single-cell RNA sequencing is performed with T cells sorted from the peripheral blood of healthy individuals and patients with B cell-acute lymphoblastic leukemia (B-ALL). ...Coupled with single-cell T cell rece …
Here, single-cell RNA sequencing is performed with T cells sorted from the peripheral blood of healthy in …
Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer.
Li J, Wu C, Hu H, Qin G, Wu X, Bai F, Zhang J, Cai Y, Huang Y, Wang C, Yang J, Luan Y, Jiang Z, Ling J, Wu Z, Chen Y, Xie Z, Deng Y. Li J, et al. Cancer Cell. 2023 Jun 12;41(6):1152-1169.e7. doi: 10.1016/j.ccell.2023.04.011. Epub 2023 May 11. Cancer Cell. 2023. PMID: 37172580
However, the underlying mechanism for pathological complete response (pCR) to immunotherapy has not been completely understood. We utilize single-cell RNA sequencing (scRNA-seq) to investigate the dynamics of immune and stromal cells in 19 patients wit …
However, the underlying mechanism for pathological complete response (pCR) to immunotherapy has not been completely understood. We utilize …
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C(+)GZMB(-)CD8(+) memory T cells and accumulation of type 2 memory T cells.
Terekhova M, Swain A, Bohacova P, Aladyeva E, Arthur L, Laha A, Mogilenko DA, Burdess S, Sukhov V, Kleverov D, Echalar B, Tsurinov P, Chernyatchik R, Husarcikova K, Artyomov MN. Terekhova M, et al. Immunity. 2023 Dec 12;56(12):2836-2854.e9. doi: 10.1016/j.immuni.2023.10.013. Epub 2023 Nov 13. Immunity. 2023. PMID: 37963457 Free article.
Here, using single-cell RNA/T cell receptor (TCR)/BCR-seq with protein feature barcoding, we profiled 317 samples from 166 healthy individuals aged 25-85 years old. ...Twelve subpopulations changed with age, including the accumulation of GZMK(+) …
Here, using single-cell RNA/T cell receptor (TCR)/BCR-seq with protein feature barcoding, we profiled 317 …
Single-cell RNA-seq reveals TOX as a key regulator of CD8(+) T cell persistence in chronic infection.
Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, Gossa S, Wherry EJ, Gattinoni L, McGavern DB, O'Shea JJ, Schwartzberg PL, Wu T. Yao C, et al. Nat Immunol. 2019 Jul;20(7):890-901. doi: 10.1038/s41590-019-0403-4. Epub 2019 Jun 17. Nat Immunol. 2019. PMID: 31209400 Free PMC article.
By comparing the single-cell transcriptomes and epigenetic profiles of CD8(+) T cells responding to acute and chronic viral infections, we found that progenitor-like CD8(+) T cells became distinct from memory precursor cells …
By comparing the single-cell transcriptomes and epigenetic profiles of CD8(+) T cells responding to acute …
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma.
Sun Y, Wu L, Zhong Y, Zhou K, Hou Y, Wang Z, Zhang Z, Xie J, Wang C, Chen D, Huang Y, Wei X, Shi Y, Zhao Z, Li Y, Guo Z, Yu Q, Xu L, Volpe G, Qiu S, Zhou J, Ward C, Sun H, Yin Y, Xu X, Wang X, Esteban MA, Yang H, Wang J, Dean M, Zhang Y, Liu S, Yang X, Fan J. Sun Y, et al. Cell. 2021 Jan 21;184(2):404-421.e16. doi: 10.1016/j.cell.2020.11.041. Epub 2020 Dec 23. Cell. 2021. PMID: 33357445 Free article.
We profiled the transcriptomes of 17,000 cells from 18 primary or early-relapse HCC cases. Early-relapse tumors have reduced levels of regulatory T cells, increased dendritic cells (DCs), and increased infiltrated CD8(+) T cells, compared with p …
We profiled the transcriptomes of 17,000 cells from 18 primary or early-relapse HCC cases. Early-relapse tumors have reduced levels of regul …
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.
Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM 2nd; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. Zhang F, et al. Nat Immunol. 2019 Jul;20(7):928-942. doi: 10.1038/s41590-019-0378-1. Epub 2019 May 6. Nat Immunol. 2019. PMID: 31061532 Free PMC article.
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T ce …
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RN …
1,032 results